Recombinant Atlantic salmon A1AT Protein (aa 1-115) (VAng-2979Lsx)

Recombinant Atlantic salmon Alpha 1 Antitrypsin Antigen is expressed in E. coli. (Uniprot ID: B5XE27)

Datasheet

Specifications

Source

E. coli

Target

Alpha 1 Antitrypsin

Type

Tumor Antigens

Applications

SDS-PAGE; WB; ELISA.

Formulation

PBS, pH 7.4.

Purity

> 95% pure by SDS-PAGE.

Storage

Store at ≤-20°C.

Antigen Information

Introduction

A1AT is a protein belonging to the serpin superfamily. It is encoded in humans by A1AT gene. As a type of enzyme inhibitor, it protects tissues from enzymes of inflammatory cells, especially neutrophil elastase, and has a reference range in blood of 0.9–2.3 g/L. When the blood contains inadequate amounts of A1AT or functionally defective A1AT (such as in alpha-1 antitrypsin deficiency), neutrophil elastase is excessively free to break down elastin, degrading the elasticity of the lungs, which results in respiratory complications, such as chronic obstructive pulmonary disease, in adults. Normally, A1AT leaves its site of origin, the liver, and joins the systemic circulation; defective A1AT can fail to do so, building up in the liver, which results in cirrhosis in either adults or children.

Alternative Names

A1AT; A1A; AAT; PI; PI1; PRO2275