Recombinant B7-H3 Protein (Leu 29- Pro 245) [Fc] [Avi] (VAng-1091Lsx)

Human B7-H3 (CD276), Fc tag, Avi tag, is expressed in HEK 293 cells. (Uniprot ID: Q5ZPR3-2)

Datasheet

Specifications

Source

HEK293 Cells.

Target

B7-H3

Type

Tumor Antigens

Applications

SDS-PAGE; WB; ELISA.

Formulation

50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH 7.5.

Purity

> 92% pure by SDS-PAGE.

Storage

Store at -20°C to -80°C.

Antigen Information

Introduction

B7-H3 is a human protein encoded by B7-H3 gene. It is an immune checkpoint molecule, is expressed by some solid tumours and is the target of anticancer candidates such as MGA271. It belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this protein.

Alternative Names

B7-H3, CD276, B7 homolog 3