Recombinant B7-H4 Protein (Met1-Ala24 & Phe29-Ala258) [His] (VAng-Cr3823)
Recombinant B7-H4 Protein (Met1-Ala24 & Phe29-Ala258) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 55 kDa. (Uniprot ID: Q7Z7D3)
Datasheet
Specifications
Source
Mammalian cells
Target
B7-H4
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
Protein lyophilized in sterile PBS/Protein store in sterile PBS.
Purity
> 90% pure by SDS-PAGE.
Storage
Store at -20 °C to -80 °C.
Antigen Information
Introduction
B7-H4 is a protein that in humans is encoded by B7-H4 gene. B7-H4 belongs to the B7 family of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands (CD28) on T lymphocytes. It inhibits T cell proliferation and cytokine production through ligation of an unknown receptor expressed by activated T cells. Notably, B7-H4 protein expression is observed in a high proportion of patients' tumors across a wide variety of malignancies. This high expression by tumors in combination with its low or absent protein expression in normal tissues makes B7-H4 an attractive immunotherapeutic target.
Alternative Names
B7H4; B7S1; B7X; B7h.5; PRO1291; VCTN1
Related Product
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
