Recombinant BTLA Protein (Met1-Ser150) [His] (VAng-Cr3837)

Recombinant BTLA Protein (Met1-Ser150) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 32 kDa. (Uniprot ID: Q7Z6A9)

Datasheet

Specifications

Source

Mammalian cells

Target

BTLA

Type

Tumor Antigens

Applications

SDS-PAGE; WB; ELISA.

Formulation

Protein lyophilized in sterile PBS/Protein store in sterile PBS.

Purity

> 90% pure by SDS-PAGE.

Storage

Store at -20 °C to -80 °C.

Antigen Information

Introduction

BTLA is a protein that in humans is encoded by BTLA gene. BTLA expression is induced during activation of T cells, and BTLA remains expressed on Th1 cells but not Th2 cells. Like PD1 and CTLA4, BTLA interacts with a B7 homolog, B7H4. However, unlike PD-1 and CTLA-4, BTLA displays T-Cell inhibition via interaction with tumor necrosis family receptors (TNF-R), not just the B7 family of cell surface receptors. BTLA is a ligand for tumour necrosis factor (receptor) superfamily, member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM). BTLA-HVEM complexes negatively regulate T-cell immune responses.

Alternative Names

BTLA1; CD272; B and T lymphocyte associated