Recombinant CD177 Protein (Leu 22-Gly 407) [His] (VAng-1202Lsx)

Human CD177, His tag, is expressed in HEK 293 cells. (Uniprot ID: Q8N6Q3-1)

Datasheet

Specifications

Source

HEK293 Cells.

Target

CD177

Type

Tumor Antigens

Applications

SDS-PAGE; WB; ELISA.

Formulation

PBS, pH 7.4.

Purity

> 90% pure by SDS-PAGE.

Storage

Store at -20°C to -80°C.

Antigen Information

Introduction

CD177 is a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis.

Alternative Names

CD177, PRV1, NB1, HNA-2a, NB1 GP