Human CD27 Protein (Thr 21-Ile 192) [Fc] (P26842-1) (VAng-1227Lsx)
Human CD27, Mouse IgG2a Fc Tag, is expressed in HEK 293 cells. (Uniprot ID: P26842-1)
Datasheet
Specifications
Source
HEK293 Cells.
Target
CD27
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
50 mM Tris, 100 mM Glycine, pH 7.5.
Purity
> 95% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
CD27 is a member of the tumor necrosis factor receptor superfamily. It is currently of interest to immunologists as a co-stimulatory immune checkpoint molecule. The protein encoded by CD27 gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kapper B and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor.
Alternative Names
CD27, TNFRSF7, S152, T14, Tp55
Related Product
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