Human CD40 Protein (Glu 21-Arg 193) [Fc] (NP_001241.1) (VAng-1312Lsx)
Human CD40, Fc tag, is expressed in HEK 293 cells. (Uniprot ID: NP_001241.1)
Datasheet
Specifications
Source
HEK293 Cells.
Target
CD40
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
Tris with Glycine, Arginine and NaCl, pH 7.5.
Purity
> 95% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions.
Alternative Names
CD40, Bp50, CDW40, MGC9013, TNFRSF5, p50
Related Product
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