Recombinant CD40 Protein (Glu 21-Arg 193) [Fc] [Avi] (VAng-1313Lsx)

Human CD40, human IgG1 Fc Tag, Avi tag, is expressed in HEK 293 cells. (Uniprot ID: P25942-1)

Datasheet

Specifications

Source

HEK293 Cells.

Target

CD40

Type

Tumor Antigens

Applications

SDS-PAGE; WB; ELISA.

Formulation

50 mM Tris, 100 mM Glycine, pH 7.5.

Purity

> 95% pure by SDS-PAGE.

Storage

Store at -20°C to -80°C.

Antigen Information

Introduction

CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions.

Alternative Names

CD40, Bp50, CDW40, MGC9013, TNFRSF5, p50