Recombinant CD44 Protein (Gln 21-Pro 220) [Fc] (VAng-1320Lsx)

Human CD44, Fc tag, is expressed in HEK 293 cells. (Uniprot ID: AAH04372)

Datasheet

Specifications

Source

HEK293 Cells.

Target

CD44

Type

Tumor Antigens

Applications

SDS-PAGE; WB; ELISA.

Formulation

Tris with Glycine, Arginine and NaCl, pH 7.5.

Purity

> 95% pure by SDS-PAGE.

Storage

Store at -20°C to -80°C.

Antigen Information

Introduction

CD44 is a cell-surface glycoprotein involved in cell–cell interactions, cell adhesion and migration. CD44 is expressed in a large number of mammalian cell types. The standard isoform, designated CD44s, comprising exons 1–5 and 16–20 is expressed in most cell types. CD44 splice variants containing variable exons are designated CD44v. Some epithelial cells also express a larger isoform (CD44E), which includes exons v8–10. CD44 is a receptor for hyaluronic acid and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). CD44 function is controlled by its posttranslational modifications. One critical modification involves discrete sialofucosylations rendering the selectin-binding glycoform of CD44 called HCELL (for Hematopoietic Cell E-selectin/L-selectin Ligand).

Alternative Names

CD44, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, Epican