Biotinylated Human CD47 Protein (Gln 19-Pro 139) [Fc] [Avi] (VAng-1333Lsx)
Biotinylated Human CD47, Fc tag and Avi tag, is expressed in HEK 293 cells. (Uniprot ID: NP_942088)
Datasheet
Specifications
Source
HEK293 Cells.
Target
CD47
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
PBS, pH 7.4.
Purity
> 95% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
CD47 is a transmembrane protein that in humans is encoded by CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha. CD-47 acts as a don't eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers, and more recently, for the treatment of pulmonary fibrosis. CD47 is involved in a range of cellular processes, including apoptosis, proliferation, adhesion, and migration. Furthermore, it plays a key role in immune and angiogenic responses.
Alternative Names
CD47, MER6, IAP, OA3
Related Product
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
