Human CD47 Protein (Gln 19-Pro 139) [Llama IgG2b Fc tag] (VAng-1336Lsx)
Human CD47, Llama IgG2b Fc tag, is expressed in HEK 293 cells. (Uniprot ID: Q08722-3)
Datasheet
Specifications
Source
HEK293 Cells.
Target
CD47
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
PBS, pH 7.4.
Purity
> 95% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
CD47 is a transmembrane protein that in humans is encoded by CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha. CD-47 acts as a don't eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers, and more recently, for the treatment of pulmonary fibrosis. CD47 is involved in a range of cellular processes, including apoptosis, proliferation, adhesion, and migration. Furthermore, it plays a key role in immune and angiogenic responses.
Alternative Names
CD47, MER6, IAP, OA3
Related Product
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