Recombinant CD70 Protein (Gln39-Pro193) [Fc] (VAng-Cr3836)
Recombinant CD70 Protein (Gln39-Pro193) fused with a Fc tag at N-terminus was expressed in Mammalian cells, with a molecular weight of monomeric:55-60, dimeric:110-120,trimeric:160-170 79.09 kDa. (Uniprot ID: P32970)
Datasheet
Specifications
Source
Mammalian cells
Target
CD70
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
Protein lyophilized in sterile PBS/Protein store in sterile PBS.
Purity
> 90% pure by SDS-PAGE.
Storage
Store at -20 °C to -80 °C.
Antigen Information
Introduction
CD70 is a ligand for CD27. The CD70 protein is expressed on highly activated lymphocytes (like in T- and B-cell lymphomas). It is therefore suggested that anti-CD70 antibodies might be a possible treatment for CD70 positive lymphomas as normal lymphocytes have low CD70 expression. ARGX-110 is a CD70-specific antibody that is currently under investigation for the treatment of hematological malignancies. It is being developed by the Belgian company arGEN-X.
Alternative Names
CD27L; CD27LG; TNFSF7
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
