Recombinant CD86 Protein (Leu 26-Pro 247) [His] (VAng-1378Lsx)
Human CD86 (B7-2), His tag, is expressed in HEK 293 cells. (Uniprot ID: AAH40261)
Applications
SDS-PAGE; WB; ELISA.
Purity
> 95% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Introduction
CD86 is a protein expressed on antigen-presenting cells that provides costimulatory signals necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells. This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.
Alternative Names
CD86, B7-2, B70, CD28LG2, LAB72, MGC34413
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