Recombinant CD86 Protein (Val 24-Glu 245) [His] (VAng-1380Lsx)
Mouse CD86 (B7-2), His tag, is expressed in HEK 293 cells. (Uniprot ID: NP_062261.3)
Datasheet
Specifications
Source
HEK293 Cells.
Target
CD86
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
50 mM Tris, 100 mM Glycine, pH 7.5.
Purity
> 95% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
CD86 is a protein expressed on antigen-presenting cells that provides costimulatory signals necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells. This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.
Alternative Names
CD86, B7-2, B70, CD28LG2, LAB72, MGC34413
Related Product
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