Recombinant Coagulation Factor II Protein (Gln 25-Glu 622) [His] (VAng-1410Lsx)
Human Coagulation Factor II (thrombin), His tag, is expressed in HEK 293 cells. (Uniprot ID: AAH51332)
Applications
SDS-PAGE; WB; ELISA.
Purity
> 95% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Introduction
F2 (Coagulation Factor II, Thrombin) is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia.
Alternative Names
thrombin, Coagulation factor II
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