Recombinant COMP Protein (Gln 21-Ala 757) [His] (VAng-1412Lsx)
Human COMP, His tag, is expressed in HEK 293 cells. (Uniprot ID: AAI25093)
Datasheet
Specifications
Source
HEK293 Cells.
Target
COMP
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
50 mM Tris, 150 mM NaCl, pH 7.5.
Purity
> 88% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
COMP (Cartilage Oligomeric Matrix Protein) is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).
Alternative Names
COMP, TSP5, EDM1, EPD1, MED, PSACH, THBS5
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