Recombinant CRBN Protein (Met1-Leu442) [His] (VAng-Cr3790)
Recombinant CRBN Protein (Met1-Leu442) fused with a His tag at N-terminus was expressed in Mammalian cells, with a molecular weight of 48.62 kDa. (Uniprot ID: Q96SW2)
Datasheet
Specifications
Source
Mammalian cells
Target
CRBN
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
Protein lyophilized in sterile PBS/Protein store in sterile PBS.
Purity
> 90% pure by SDS-PAGE.
Storage
Store at -20 °C to -80 °C.
Antigen Information
Introduction
CRBN is a protein that in humans is encoded by CRBN gene. The gene that encodes the cereblon protein is found on the human chromosome 3, on the short arm at position p26.3 from base pair 3,190,676 to base pair 3,221,394. CRBN orthologs are highly conserved from plants to human. Mutations in this gene are associated with autosomal recessive nonsyndromic intellectual disability, possibly as a result of dysregulation of calcium-activated potassium channels in the brain during development. It can also bind to the large-conductance calcium-activated potassium channel (KCNMA1) and regulates its activity.
Alternative Names
MRT2; MRT2A; Cereblon
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