Recombinant Cynomolgus CD20 Protein (aa 213-297) [His] (VAng-Cr3916)
Recombinant Cynomolgus CD20 Protein (Glu213-Pro297) fused with a His tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 12.1 kDa. (Accession ID: NP_001274241.1)
Datasheet
Specifications
Source
Cynomolgus
Target
CD20
Type
Tumor Antigens
Applications
ELISA.
Formulation
Lyophilized from sterile PBS, pH 7.4.
Purity
> 97% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
CD20 is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R+, CD117+) and progressively increasing in concentration until maturity. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The protein has no known natural ligand and its function is to enable optimal B-cell immune response, specifically against T-independent antigens. It is suspected that it acts as a calcium channel in the cell membrane. CD20 is expressed on all stages of B cell development except the first and last; it is present from late pro-B cells through memory cells, but not on either early pro-B cells or plasma blasts and plasma cells.
Alternative Names
MS4A1; B1; Bp35; CD20; CVID5; LEU-16; MS4A2; S7
Related Product
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