Recombinant Cynomolgus PD-1 Protein (aa 1-167) [AVI] (VAng-Cr4031)
Recombinant Cynomolgus PD-1 Protein (Met1-Gln167) fused with a AVI tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 44.5 kDa. (Accession ID: NP_001271065.1)
Datasheet
Specifications
Source
Cynomolgus
Target
PD-1
Type
Tumor Antigens
Applications
ELISA.
Formulation
Lyophilized from sterile PBS, pH 7.4.
Purity
> 95% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
PD-1 is a protein on the surface of cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the immune system and promoting self-tolerance by suppressing T cell inflammatory activity. This prevents autoimmune diseases, but it can also prevent the immune system from killing cancer cells. It is an immune checkpoint and guards against autoimmunity through two mechanisms. First, it promotes apoptosis (programmed cell death) of antigen-specific T-cells in lymph nodes. Second, it reduces apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells).
Alternative Names
CD279; PD-1; SLEB2; hPD-1; hPD-l; hSLE1; Programmed cell death 1
Related Product
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