Recombinant Cynomolgus PD-L2 Protein (aa 1-219) [Fc] (VAng-Cr4039)

Recombinant Cynomolgus PD-L2 Protein (Met1-Pro219) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 49.6 kDa. (Accession ID: A4GW30)

Datasheet

Specifications

Source

Cynomolgus

Target

PD-L2

Type

Tumor Antigens

Applications

ELISA.

Formulation

Lyophilized from sterile PBS, pH 7.4.

Purity

> 95% pure by SDS-PAGE.

Storage

Store at -20°C to -80°C.

Antigen Information

Introduction

PD-L2, also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and B7-H3. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain, a transmembrane region, and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells, placental endothelium and medullary thymic epithelial cells, and can be induced by LPS in B cells, INF-gamma; in monocytes, or LPS plus IFN-gamma; in dendritic cells. The CD28 and B7 protein families are critical regulators of immune responses. PD-L2 and PD-L1 are two ligands for PD-1, member of the CD28/CTLA4 family expressed on activated lymphoid cells, and thus provide signals for regulating T cell activation and immune tolerance. The interaction of B7-DC/PD-1 exhibited a 2-6-fold higher affinity compared with the interaction of B7-H1/PD-1.

Alternative Names

PDCD1LG2; B7DC; Btdc; CD273; PDCD1L2; PDL2; bA574F11.2; programmed cell death 1 ligand 2