Recombinant DR6 Protein (Gln 42-Leu 350) [Fc] (VAng-1473Lsx)
Human DR6 (TNFRSF25), Fc tag, is expressed in HEK 293 cells. (Uniprot ID: AAH17730)
Datasheet
Specifications
Source
HEK293 Cells.
Target
DR6
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
50 mM Tris, 100 mM Glycine, pH 7.5.
Purity
> 90% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
TNFRSF21 (TNF Receptor Superfamily Member 21) is a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation.
Alternative Names
TNFRSF21, DR6, CD358, BM-018
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