EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis. Diseases associated with EPHB4 include Capillary Malformation-Arteriovenous Malformation 2 and Lymphatic Malformation 7.