Human ErbB3 Protein (Ser 20-Thr 643) [Fc] (P21860-1) (VAng-1509Lsx)

Human ErbB3 (Her3), Mouse IgG2a Fc Tag, is expressed in HEK 293 cells. (Uniprot ID: P21860-1)

Datasheet

Specifications

Source

HEK293 Cells.

Target

ERBB3

Type

Tumor Antigens

Applications

SDS-PAGE; WB; ELISA.

Formulation

Tris with Glycine, Arginine and NaCl, pH 7.5.

Purity

> 95% pure by SDS-PAGE.

Storage

Store at -20°C to -80°C.

Antigen Information

Introduction

ERBB3 is a member of the epidermal growth factor receptor (EGFR/ERBB) family of receptor tyrosine kinases. The kinase-impaired ERBB3 is known to form active heterodimers with other members of the ErbB family, most notably the ligand binding-impaired ErbB2. It is expressed in skin, bone, muscle, nervous system, heart, lungs, and intestinal epithelium. It consists of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain contains four subdomains (I-IV). Subdomains I and III are leucine-rich and are primarily involved in ligand binding. Subdomains II and IV are cysteine-rich and most likely contribute to protein conformation and stability through the formation of disulfide bonds.

Alternative Names

ERBB3, HER3, LCCS2, MDA-BF-1, MGC88033, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3