Recombinant GLP1R Protein (Arg24-Tyr145) [His] (VAng-Cr3779)
Recombinant GLP1R Protein (Arg24-Tyr145) fused with a His tag at N-terminus was expressed in Mammalian cells, with a molecular weight of 45-66 kDa. (Uniprot ID: P43220)
Datasheet
Specifications
Source
Mammalian cells
Target
GLP1R
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
Protein lyophilized in sterile PBS/Protein store in sterile PBS.
Purity
> 90% pure by SDS-PAGE.
Storage
Store at -20 °C to -80 °C.
Antigen Information
Introduction
GLP1R is a receptor protein found on beta cells of the pancreas. It is involved in the control of blood sugar level by enhancing insulin secretion. It is a member of the glucagon receptor family of G protein-coupled receptors. GLP1R is composed of two domains, one extracellular (ECD) that binds the C-terminal helix of GLP-1, and one transmembrane (TMD) domain that binds the N-terminal region of GLP-1. In the TMD domain there is fulcrum of polar residues that regulates the biased signaling of the receptor while the transmembrane helical boundaries and extracellular surface are a trigger for biased agonism.
Alternative Names
GLP-1; GLP-1-R; GLP-1R
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