Recombinant HAVCR2 Protein (Met1-Arg200) [His] (VAng-Cr3813)
Recombinant HAVCR2 Protein (Met1-Arg200) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 40 kDa. (Uniprot ID: Q8TDQ0)
Datasheet
Specifications
Source
Mammalian cells
Target
HAVCR2
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
Protein lyophilized in sterile PBS/Protein store in sterile PBS.
Purity
> 90% pure by SDS-PAGE.
Storage
Store at -20 °C to -80 °C.
Antigen Information
Introduction
HAVCR2 is a protein that in humans is encoded by HAVCR2 gene. HAVCR2 belongs to TIM family cell surface receptor proteins. These proteins share a similar structure, in which the extracellular region consists of membrane distal single variable immunoglobulin domain (IgV) and a glycosylated mucin domain of variable length located closer to the membrane. Intracellular domain of HAVCR2 is called C-terminal cytoplasmic tail. It contains five conserved tyrosine residues that interact with multiple components of T-cell receptor (TCR) complex and negatively regulates its function. HAVCR2 is an immune checkpoint and together with other inhibitory receptors including programmed cell death protein 1 (PD-1) and lymphocyte activation gene 3 protein (LAG3) mediate the CD8+ T-cell exhaustion.
Alternative Names
HAVcr-2; KIM-3; TIM3; TIMD-3; TIMD3; Tim-3; CD366; hepatitis A virus cellular receptor 2
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