Recombinant Hepatitis C virus polyprotein NS4, an artificial mosaic polypeptide composite constructed from fragments of the NS-4 immunodominant region of 11 different HCV genotypes, expressed in E. coli, MW 66 kDa. 1.00 mg/mL.
8 M Urea, 20 mM TRIS, pH 9.0 containing 10 mM DTT, 1 mM EDTA and 0.5% Tween-20.
Purity
> 95% pure by SDS-PAGE.
Storage
Store at -20°C.
Antigen Information
Introduction
Hepatitis C virus (HCV) is a member of the Flaviviridae family, genus hepacivirus. HCV is a small (55-65 nm in size), enveloped, positive-sense single-stranded RNA virus. E1 and E2 are two type 1 transmembrane glycoproteins that are essential components of the envelope. They can assemble as non-covalent heterodimers and are necessary for viral entry and fusion. Hepatitis C virus is the cause of hepatitis C and some cancers such as liver cancer (hepatocellular carcinoma, abbreviated HCC) and lymphomas in humans.