Recombinant Human A1ACT Protein (aa 24-423) (HEK 293 Cells) (VAng-2970Lsx)

Recombinant Human Alpha 1 Antichymotrypsin Antigen is expressed in HEK 293 Cells. (Uniprot ID: P01011)

Datasheet

Specifications

Source

E. coli

Target

Alpha 1 Antichymotrypsin

Type

Tumor Antigens

Applications

SDS-PAGE; WB; ELISA.

Formulation

PBS, pH 7.4.

Purity

> 95% pure by SDS-PAGE.

Storage

Store at ≤-20°C.

Antigen Information

Introduction

A1ACT is an alpha globulin glycoprotein that is a member of the serpin superfamily. In humans, it is encoded by A1ACT gene. Alpha 1-antichymotrypsin inhibits the activity of certain enzymes called proteases, such as cathepsin G that is found in neutrophils, and chymases found in mast cells, by cleaving them into a different shape or conformation. This activity protects some tissues, such as the lower respiratory tract, from damage caused by proteolytic enzymes. This protein is produced in the liver, and is an acute phase protein that is induced during inflammation. Deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.

Alternative Names

A1ACT; AACT; ACT; GIG24; GIG25