Recombinant Human BTLA Protein (aa 31-150) [Fc] (VAng-3836Lsx)
Recombinant Human BTLA protein, expressed in HEK 293 cells. (Uniprot ID: Q7Z6A9)
Datasheet
Specifications
Source
HEK293 Cells
Target
BTLA
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
20 mM PB, 150 mM NaCl, pH 7.4.
Purity
> 95% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
BTLA is a protein that in humans is encoded by BTLA gene. BTLA expression is induced during activation of T cells, and BTLA remains expressed on Th1 cells but not Th2 cells. Like PD1 and CTLA4, BTLA interacts with a B7 homolog, B7H4. However, unlike PD-1 and CTLA-4, BTLA displays T-Cell inhibition via interaction with tumor necrosis family receptors (TNF-R), not just the B7 family of cell surface receptors. BTLA is a ligand for tumour necrosis factor (receptor) superfamily, member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM). BTLA-HVEM complexes negatively regulate T-cell immune responses.
Alternative Names
BTLA, CD272
Related Product
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
