Recombinant Human c-Met Protein (aa 1-932) [Fc] (VAng-Cr4007)

Recombinant Human c-Met Protein (Met 1-Thr 932) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 129.5 kDa. (Accession ID: NP_000236)

Datasheet

Specifications

Source

Human

Target

c-Met

Type

Tumor Antigens

Applications

ELISA.

Formulation

Lyophilized from sterile PBS, pH 7.4.

Purity

> 95% pure by SDS-PAGE.

Storage

Store at -20°C to -80°C.

Antigen Information

Introduction

c-Met is a single pass tyrosine kinase receptor essential for embryonic development, organogenesis and wound healing. Hepatocyte growth factor/Scatter Factor (HGF/SF) and its splicing isoform (NK1, NK2) are the only known ligands of the MET receptor. MET is normally expressed by cells of epithelial origin, while expression of HGF/SF is restricted to cells of mesenchymal origin. Abnormal MET activation in cancer correlates with poor prognosis, where aberrantly active MET triggers tumor growth, formation of new blood vessels (angiogenesis) that supply the tumor with nutrients, and cancer spread to other organs (metastasis). MET is deregulated in many types of human malignancies, including cancers of kidney, liver, stomach, breast, and brain. Normally, only stem cells and progenitor cells express MET, which allows these cells to grow invasively in order to generate new tissues in an embryo or regenerate damaged tissues in an adult.

Alternative Names

MET; MET proto-oncogene; receptor tyrosine kinase; AUTS9; HGFR; RCCP2