Recombinant Human CD146 / MCAM Protein (aa 1-559) [His] (VAng-Cr3908)

Recombinant Human CD146 / MCAM Protein (Met 1-Gly 559) fused with a His tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 61.3 kDa. (Accession ID: NP_006491.2)

Datasheet

Specifications

Source

Human

Target

CD146 / MCAM

Type

Tumor Antigens

Applications

ELISA.

Formulation

Lyophilized from sterile PBS, pH 7.4.

Purity

> 98% pure by SDS-PAGE.

Storage

Store at -20°C to -80°C.

Antigen Information

Introduction

The CD146 antigen, also known as melanoma cell adhesion molecule (MCAM) and MUC18, is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 contains the characteristic immunoglobulin-like domains (V-V-C2-C2-C2), a transmembrane region and a short cytoplasmic tail. The CD146 expression is detected in endothelial cells in vascular tissue throughout the body, and plays a role in cell adhesion, as well as in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. As a cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor, CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis, or immune recognition. This protein is also expressed predominantly on metastatic lesions and advanced primary tumours, and thus has been suggested to play an important role in tumour progression and the development of metastasis in certain human carcinomas.

Alternative Names

MUC18; melanoma cell adhesion molecule; HEMETCAM; MelCAM