Recombinant Human CD27 Protein (aa 1-192) [Fc] (P26842) (VAng-Cr3922)

Recombinant Human CD27 Protein (Met1-Ile192) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 44.4 kDa. (Accession ID: P26842)

Datasheet

Specifications

Source

Human

Target

CD27

Type

Tumor Antigens

Applications

ELISA.

Formulation

Lyophilized from sterile PBS, pH 7.4.

Purity

> 95% pure by SDS-PAGE.

Storage

Store at -20°C to -80°C.

Antigen Information

Introduction

CD27 is a member of the tumor necrosis factor receptor superfamily. It is currently of interest to immunologists as a co-stimulatory immune checkpoint molecule. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.

Alternative Names

S152; S152. LPFS2; T14; TNFRSF7; Tp55