Recombinant Human CTLA-4 Protein (aa 1-162) [Fc] (40.7 kDa) (VAng-Cr3948)

Recombinant Human CTLA-4 Protein (Met1-Phe162) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 40.7 kDa. (Accession ID: NP_005205.2)

Datasheet

Specifications

Source

Human

Target

CTLA-4

Type

Tumor Antigens

Applications

ELISA.

Formulation

Lyophilized from sterile PBS, pH 7.4.

Purity

> 95% pure by SDS-PAGE.

Storage

Store at -20°C to -80°C.

Antigen Information

Introduction

CTLA-4 is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses. CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation – a phenomenon which is particularly notable in cancers. It acts as an off switch when bound to CD80 or CD86 on the surface of antigen-presenting cells. CTLA4 is a member of the immunoglobulin superfamily that is expressed by activated T cells and transmits an inhibitory signal to T cells. CTLA4 is homologous to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells.

Alternative Names

ALPS5; CD; CD152; CELIAC3; CTLA-4; GRD4; GSE; IDDM12; cytotoxic T-lymphocyte associated protein 4