Recombinant Human EpCAM Protein (aa 1-265) [Fc] (HEK293) (VAng-Cr3981)
Recombinant Human EpCAM Protein (Met1-Lys265) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 54 kDa. (Accession ID: NP_002345.1)
Datasheet
Specifications
Source
Human
Target
EpCAM
Type
Tumor Antigens
Applications
ELISA.
Formulation
Lyophilized from sterile PBS, pH 7.4.
Purity
> 95% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
EPCAM is a transmembrane glycoprotein mediating Ca2+ independent homotypic cell–cell adhesion in epithelia. It is also involved in cell signaling, migration, proliferation, and differentiation. It has oncogenic potential via its capacity to upregulate c-myc, e-fabp. EPCAM is expressed exclusively in epithelia and epithelial-derived neoplasms, EPCAM can be used as diagnostic marker for various cancers. It appears to play a role in tumorigenesis and metastasis of carcinomas, so it can also act as a potential prognostic marker and as a potential target for immunotherapeutic strategies.
Alternative Names
GA733-2; M1S2; M4S1; MIC18; TACSTD1; TROP1
Related Product
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
