Recombinant Human ERBB2 Protein (aa 676-1255) [GST] (VAng-Cr3986)
Recombinant Human ERBB2 Protein (Lys 676-Val 1255) fused with a GST tag at N-terminus was expressed in Baculovirus-Insect Cells, with a molecular weight of 92 kDa. (Accession ID: NP_004439.2)
Datasheet
Specifications
Source
Human
Target
ERBB2
Type
Tumor Antigens
Applications
ELISA.
Formulation
Lyophilized from sterile PBS, pH 7.4.
Purity
> 85% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
ERBB2 is a protein that in humans is encoded by ERBB2. It has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
Alternative Names
HER-2;HER-2/neu;HER2;MLN 19;MLN19;NEU;NGL;TKR1
Related Product
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