Recombinant Human ERBB3 Protein (aa 1-643) [Fc] (VAng-Cr3988)

Recombinant Human ERBB3 Protein (Met 1-Thr 643) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 95.4 kDa. (Accession ID: NP_001973.2)

Datasheet

Specifications

Source

Human

Target

ERBB3

Type

Tumor Antigens

Applications

ELISA.

Formulation

Lyophilized from sterile PBS, pH 7.4.

Purity

> 90% pure by SDS-PAGE.

Storage

Store at -20°C to -80°C.

Antigen Information

Introduction

ERBB2 is a protein that in humans is encoded by ERBB2. It has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

Alternative Names

HER-2;HER-2/neu;HER2;MLN 19;MLN19;NEU;NGL;TKR1