Recombinant Human ERBB3 Protein (aa 730-1065) [GST] (VAng-Cr3990)
Recombinant Human ERBB3 Protein (Pro 730-Ser 1065) fused with a GST tag at N-terminus was expressed in HEK293 Cells, with a molecular weight of 65 kDa. (Accession ID: NP_001973.2)
Datasheet
Specifications
Source
Human
Target
ERBB3
Type
Tumor Antigens
Applications
ELISA.
Formulation
Lyophilized from sterile PBS, pH 7.4.
Purity
> 75% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
ERBB3 is a member of the epidermal growth factor receptor (EGFR/ERBB) family of receptor tyrosine kinases. The kinase-impaired ERBB3 is known to form active heterodimers with other members of the ErbB family, most notably the ligand binding-impaired ErbB2. It is expressed in skin, bone, muscle, nervous system, heart, lungs, and intestinal epithelium. It consists of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain contains four subdomains (I-IV). Subdomains I and III are leucine-rich and are primarily involved in ligand binding. Subdomains II and IV are cysteine-rich and most likely contribute to protein conformation and stability through the formation of disulfide bonds.
Alternative Names
ErbB-3; HER3; LCCS2; MDA-BF-1
Related Product
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