Recombinant Human ErbB4 Protein (aa 1-649) [His] (Baculovirus) (VAng-Cr3994)

Recombinant Human ErbB4 Protein (Met1-Arg649) fused with a His tag at C-terminus was expressed in Baculovirus-Insect Cells, with a molecular weight of 71.1 kDa. (Accession ID: NP_005226.1)

Datasheet

Specifications

Source

Human

Target

ErbB4

Type

Tumor Antigens

Applications

ELISA.

Formulation

Lyophilized from sterile PBS, pH 7.4.

Purity

> 95% pure by SDS-PAGE.

Storage

Store at -20°C to -80°C.

Antigen Information

Introduction

ErbB4 is an enzyme that in humans. Receptor tyrosine-protein kinase erbB-4 is a receptor tyrosine kinase that is a member of the epidermal growth factor receptor subfamily. ERBB4 is a single-pass type I transmembrane protein with multiple furin-like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins-2 and -3, heparin-binding EGF-like growth factor and betacellulin. Ligand binding induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Other single-nucleotide polymorphisms and a risk haplotype have been linked to schizophrenia. Single-nucleotide polymorphisms in ERBB4 have also been found in a study of patients with familial amyotrophic lateral sclerosis type 19.

Alternative Names

ALS19; HER4; p180erbB4; erb-b2 receptor tyrosine kinase 4