Recombinant Human NGF Protein (aa 122-239) (VAng-Cr4024)

Recombinant Human NGF Protein (Ser122-Arg239) was expressed in CHO Stable Cells, with a molecular weight of 13.2 kDa. (Accession ID: NP_002497.2)

Datasheet

Specifications

Source

Human

Target

NGF

Type

Tumor Antigens

Applications

ELISA.

Formulation

Lyophilized from sterile 20mM NaAc, 150mM NaCl, pH 5.5.

Purity

> 95% pure by SDS-PAGE.

Storage

Store at -20°C to -80°C.

Antigen Information

Introduction

NGF is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. NGF is initially in a 7S, 130-kDa complex of 3 proteins - Alpha-NGF, Beta-NGF, and Gamma-NGF (2:1:2 ratio) when expressed. This form of NGF is also referred to as proNGF (NGF precursor). The gamma subunit of this complex acts as a serine protease, and cleaves the N-terminal of the beta subunit, thereby activating the protein into functional NGF. As its name suggests, NGF is involved primarily in the growth, as well as the maintenance, proliferation, and survival of nerve cells (neurons). In fact, NGF is critical for the survival and maintenance of sympathetic and sensory neurons, as they undergo apoptosis in its absence. However, several recent studies suggest that NGF is also involved in pathways besides those regulating the life cycle of neurons. NGF can drive the expression of genes such as bcl-2 by binding to the TrkA receptor, which stimulates the proliferation and survival of the target neuron.

Alternative Names

Beta-HSAN5; NGFB; nerve growth factor