Recombinant Human PD-1 Protein (aa 1-167) [Fc] (VAng-Cr4028)

Recombinant Human PD-1 Protein (Met1-Gln167) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 42.3 kDa. (Accession ID: NP_005009.2)

Datasheet

Specifications

Source

Human

Target

PD-1

Type

Tumor Antigens

Applications

ELISA.

Formulation

Lyophilized from sterile PBS, pH 7.4.

Purity

> 95% pure by SDS-PAGE.

Storage

Store at -20°C to -80°C.

Antigen Information

Introduction

PD-1 is a protein on the surface of cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the immune system and promoting self-tolerance by suppressing T cell inflammatory activity. This prevents autoimmune diseases, but it can also prevent the immune system from killing cancer cells. It is an immune checkpoint and guards against autoimmunity through two mechanisms. First, it promotes apoptosis (programmed cell death) of antigen-specific T-cells in lymph nodes. Second, it reduces apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells).

Alternative Names

CD279; PD-1; SLEB2; hPD-1; hPD-l; hSLE1; Programmed cell death 1