Recombinant Human TGFBR2 Protein (aa 1-166) [His] (VAng-Cr4048)
Recombinant Human TGFBR2 Protein (Met1-Gln166) fused with a His tag at C-terminus was expressed in Baculovirus-Insect Cells, with a molecular weight of 17.7 kDa. (Accession ID: NP_003233.4)
Formulation
Lyophilized from sterile 20 mM PBS, pH 7.0, 150 mM NaCl,10%glycerol,0.5 mM TCEP.
Purity
> 95% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Introduction
TGFBR2 is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. TGF beta receptor 2 consists of a C-terminal protein kinase domain and an N-terminal ectodomain. The ectodomain consists of a compact fold containing nine beta-strands and a single helix stabilised by a network of six intra strand disulphide bonds. The folding topology includes a central five-stranded antiparallel beta-sheet, eight-residues long at its centre, covered by a second layer consisting of two segments of two-stranded antiparallel beta-sheets (beta1-beta4, beta3-beta9).
Alternative Names
AAT3; FAA3; LDS1B; LDS2; LDS2B; MFS2; RIIC; TAAD2; TGFR-2; TGFbeta-RII
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