Recombinant IAV H15N8 Hemagglutinin / HA Protein (aa 1-534) [His] (VAng-Wyb6933)

HEK293 Cells.

Influenza A Virus

Viral Antigens

Used for WB, SDS-PAGE.

PBS, pH 7.4.

> 97% pure by SDS-PAGE.

Store at -20°C to -80°C.

H15N8 is a subtype of Influenza A. Hemagglutinin (HA) is a single-pass type I integral membrane glycoprotein from the influenza virus, and comprises over 80 % of the envelope proteins present in the virus particle. The HA is a trimer with a receptor binding pocket on the globular head of each monomer. In natural infection, inactive HA is matured into HA1 and HA2 outside the cell by one or more trypsin-like, arginine-specific endoprotease secreted by the bronchial epithelial cells. Binding of HA to sialic acid-containing receptors on the surface of its target cell brings about the attachment of the virus particle to the cell and forms a endosome. Low pH in endosomes induce an irreversible conformational change in HA2, releasing the hydrophobic portion "fusion peptide". After which, virus penetrates the cell and pours its contents including the RNA genome into the cytoplasm mediated by fusion of the endocytosed virus particle's own membrane and the endosomal membrane. Hemagglutinin plays a major role in the determination of host range restriction and virulence.

Influenza A virus subtype H15N8; H15N8