Recombinant IDO Protein (Ala2-Gly403) [His] (VAng-Cr3825)

Recombinant IDO Protein (Ala2-Gly403) fused with a His tag at N-terminus was expressed in Mammalian cells, with a molecular weight of 44 kDa. (Uniprot ID: P14902)

Datasheet

Specifications

Source

Mammalian cells

Target

IDO

Type

Tumor Antigens

Applications

SDS-PAGE; WB; ELISA.

Formulation

Protein lyophilized in sterile PBS/Protein store in sterile PBS.

Purity

> 90% pure by SDS-PAGE.

Storage

Store at -20 °C to -80 °C.

Antigen Information

Introduction

IDO is a heme-containing enzyme that in humans is encoded by IDO gene. It is one of three enzymes that catalyze the first and rate-limiting step in the kynurenine pathway, the O2-dependent oxidation of L-tryptophan to N-formylkynurenine, the others being IDO2 and tryptophan 2,3-dioxygenase (TDO). IDO has been implicated in immune modulation through its ability to limit T-cell function and engage mechanisms of immune tolerance. Emerging evidence suggests that IDO becomes activated during tumor development, helping malignant cells escape eradication by the immune system.

Alternative Names

Identifiers
Aliases IDO1; IDO; IDO-1; INDO; indoleamine 2;3-dioxygenase 1

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