Recombinant IDO Protein (Ala2-Gly403) [His] (VAng-Cr3825)
Recombinant IDO Protein (Ala2-Gly403) fused with a His tag at N-terminus was expressed in Mammalian cells, with a molecular weight of 44 kDa. (Uniprot ID: P14902)
Datasheet
Specifications
Source
Mammalian cells
Target
IDO
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
Protein lyophilized in sterile PBS/Protein store in sterile PBS.
Purity
> 90% pure by SDS-PAGE.
Storage
Store at -20 °C to -80 °C.
Antigen Information
Introduction
IDO is a heme-containing enzyme that in humans is encoded by IDO gene. It is one of three enzymes that catalyze the first and rate-limiting step in the kynurenine pathway, the O2-dependent oxidation of L-tryptophan to N-formylkynurenine, the others being IDO2 and tryptophan 2,3-dioxygenase (TDO). IDO has been implicated in immune modulation through its ability to limit T-cell function and engage mechanisms of immune tolerance. Emerging evidence suggests that IDO becomes activated during tumor development, helping malignant cells escape eradication by the immune system.
Alternative Names
Identifiers
Aliases IDO1; IDO; IDO-1; INDO; indoleamine 2;3-dioxygenase 1
Aliases IDO1; IDO; IDO-1; INDO; indoleamine 2;3-dioxygenase 1
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