Recombinant IKZF1 Protein (Met1-Ser519) [MYC/DDK] (VAng-Cr3791)
Recombinant IKZF1 Protein (Met1-Ser519) fused with a MYC/DDK tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 57.09 kDa. (Uniprot ID: Q13422)
Datasheet
Specifications
Source
Mammalian cells
Target
IKZF1
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
Protein lyophilized in sterile PBS/Protein store in sterile PBS.
Purity
> 90% pure by SDS-PAGE.
Storage
Store at -20 °C to -80 °C.
Antigen Information
Introduction
IKZF1 is a protein that in humans is encoded by IKZF1 gene. It has been found in recent years to be a major tumor suppressor involved in human B-cell acute lymphoblastic leukemia. IKZF1 is upregulated in granulocytes, B cells, CD4 and CD8 T cells, and NK cells, and downregulated in erythroblasts, megakaryocytes and monocytes. SNPs located near the 3' region of IKZF1 in humans have been linked to susceptibility to childhood acute lymphoblastic leukemia (ALL) as well as type I diabetes. It also displays crucial functions in the hematopoietic system and its loss of function has been linked to the development of lymphoid leukemia.
Alternative Names
IK1; IKAROS; LYF1; ZNFN1A1
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