Recombinant IL13 Protein (Gly35-Asn146) [Fc] (VAng-Cr3806)

Recombinant IL13 Protein (Gly35-Asn146) fused with a Fc tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 50-55 kDa. (Uniprot ID: P35225)

Datasheet

Specifications

Source

Mammalian cells

Target

IL13

Type

Tumor Antigens

Applications

SDS-PAGE; WB; ELISA.

Formulation

Protein lyophilized in sterile PBS/Protein store in sterile PBS.

Purity

> 90% pure by SDS-PAGE.

Storage

Store at -20 °C to -80 °C.

Antigen Information

Introduction

IL13 is a protein that in humans is encoded by IL13 gene. It has a mass of 13 kDa and folds into 4 alpha helical bundles. The secondary structural features of IL-13 are similar to that of Interleukin 4 (IL-4), however it only has 25% sequence homology to IL-4 and is capable of IL-4 independent signaling. IL-13 is a cytokine secreted by T helper type 2 (Th2) cells, CD4 cells, Natural killer T cell, Mast cell, Basophil cells, Eosinophil cells and Nuocyte cells. Interleukin-13 is a central regulator in IgE synthesis, goblet cell hyperplasia, mucus hypersecretion, airway hyperresponsiveness, fibrosis and chitinase up-regulation. It is a mediator of allergic inflammation and different diseases including asthma.

Alternative Names

IL-13; P600; interleukin 13