Recombinant INSR Protein (Met1-Ser758) [His] (VAng-Cr3793)

Recombinant INSR Protein (Met1-Ser758) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 83.38 kDa. (Uniprot ID: P06213)

Datasheet

Specifications

Source

Mammalian cells

Target

INSR

Type

Tumor Antigens

Applications

SDS-PAGE; WB; ELISA.

Formulation

Protein lyophilized in sterile PBS/Protein store in sterile PBS.

Purity

> 90% pure by SDS-PAGE.

Storage

Store at -20 °C to -80 °C.

Antigen Information

Introduction

INSR is a protein that in humans is encoded by INSR gene. It is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of tyrosine kinase receptors. Metabolically, the insulin receptor plays a key role in the regulation of glucose homeostasis, a functional process that under degenerate conditions may result in a range of clinical manifestations including diabetes and cancer. Transcription of alternative splice variants derived from the INSR gene are translated to form one of two monomeric isomers; IR-A in which exon 11 is excluded, and IR-B in which exon 11 is included. Inclusion of exon 11 results in the addition of 12 amino acids upstream of the intrinsic furin proteolytic cleavage site.

Alternative Names

CD220; HHF5; insulin receptor