Recombinant ITGAL Protein (Met1-Leu1090) [His] (VAng-Cr3759)
Recombinant ITGAL Protein (Met1-Leu1090) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 160 kDa. (Uniprot ID: P20701)
Datasheet
Specifications
Source
Mammalian cells
Target
ITGAL
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
Protein lyophilized in sterile PBS/Protein store in sterile PBS.
Purity
> 90% pure by SDS-PAGE.
Storage
Store at -20 °C to -80 °C.
Antigen Information
Introduction
ITGAL is involved in cellular adhesion and costimulatory signaling. It is the target of the drug efalizumab. ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling.
Alternative Names
CD11A; ITGAL
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