Recombinant Mouse CD27 Protein (aa 1-182) [Fc] (VAng-Cr3923)
Recombinant Mouse CD27 Protein (Met 1-Arg 182) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 46.2 kDa. (Accession ID: NP_001028298.1)
Formulation
Lyophilized from sterile PBS, pH 7.4.
Purity
> 94% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Introduction
CD27 is a member of the tumor necrosis factor receptor superfamily. It is currently of interest to immunologists as a co-stimulatory immune checkpoint molecule. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
Alternative Names
S152; S152. LPFS2; T14; TNFRSF7; Tp55
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