Recombinant MPL Protein (Met1-Trp491) [His] (VAng-Cr3767)
Recombinant MPL Protein (Met1-Trp491) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 66-76 kDa. (Uniprot ID: P40238)
Datasheet
Specifications
Source
Mammalian cells
Target
MPL
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
Protein lyophilized in sterile PBS/Protein store in sterile PBS.
Purity
> 90% pure by SDS-PAGE.
Storage
Store at -20 °C to -80 °C.
Antigen Information
Introduction
MPL is a protein that in humans is encoded by the MPL (myeloproliferative leukemia virus) oncogene. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin, CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.
Alternative Names
MPL
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