Recombinant PD-L1 Protein (Met1-Arg238) [His] (VAng-Cr3817)
Recombinant PD-L1 Protein (Met1-Arg238) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 35 kDa. (Uniprot ID: Q9NZQ7)
Datasheet
Specifications
Source
Mammalian cells
Target
PD-L1
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
Protein lyophilized in sterile PBS/Protein store in sterile PBS.
Purity
> 90% pure by SDS-PAGE.
Storage
Store at -20 °C to -80 °C.
Antigen Information
Introduction
PD-L1 is a protein that in humans is encoded by PD-L1 gene. It is a 40kDa type I transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis. Normally the immune system reacts to foreign antigens that are associated with exogenous or endogenous danger signals, which triggers a proliferation of antigen-specific CD8+ T cells and/or CD4+ helper cells. The binding of PD-L1 to PD-1 or B7.1 transmits an inhibitory signal that reduces the proliferation of antigen-specific T-cells in lymph nodes, while simultaneously reducing apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells) - further mediated by a lower regulation of the gene Bcl-2.
Alternative Names
B7-H; B7H1; PDCD1L1; PDCD1LG1; PDL1; CD274 molecule; Programmed cell death 1 ligand 1
Related Product
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
