Recombinant Rat CD22 Protein (aa 1-692) [Fc] (VAng-Cr3920)

Recombinant Rat CD22 Protein (Met1-Arg692) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 102 kDa. (Accession ID: NP_001100973.1)

Datasheet

Specifications

Source

Rat

Target

CD22

Type

Tumor Antigens

Applications

ELISA.

Formulation

Lyophilized from sterile PBS, pH 7.4.

Purity

> 95% pure by SDS-PAGE.

Storage

Store at -20°C to -80°C.

Antigen Information

Introduction

CD22 is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases. CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer's patches in mice.

Alternative Names

SIGLEC-2; SIGLEC2; CD22 molecule